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In intoxication conditions, the pharmacokinetics and excretion of these metabolites can not be totally evaluated in many circumstances, due to initial sampling is carried out all through scientific cares after intoxication diagnosis. At this point, in vivo experiments in model animals offer details about the metabolism of a particular material, and also the distribution of the mother or father compound and/or metabolites in numerous tissues together some time, such as the excretion of those compounds25.

Yet, the instrumental reaction noticed in negative ionisation was lower than in positive and, for that, knowledge evaluation was carried out only in beneficial method.

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